The story of JoJo's Bizarre Adventure centers around the misadventures of the Joestars, a powerful family with English roots. Each member of the bloodline has a star shaped birthmark above their left shoulder blade – Dio Brando, the original nemesis of the Joestar family, and his descendants have this distinguishable mark also, a result from Dio's 'theft' of Jonathan Joestar's body and inheriting the Joestar genes as well. The series spans several generations, with each part featuring a descendent of the Joestars as the main protagonist along with a large cast of characters.