Been playing this game alot lately.... Made a few chars and went down different paths with each.
First advice... always get some kind of armor with a high DT... the one I always get... because of its uniqueness, lightness... and high dt... is the chinese stealth armor... its extremely easy to get... you can get it at level one... just gotta walk to hoover dam...
Also... Myself on different characters I specialized in different weapon styles... my favorite was small arms (pistols) because there are a rediculous amount of perks that benefit it, at high levels I was able to kill super mutants in about 3 shots with the "Mysterious Magnum" I was using hollowpoints.
The one that new vegas chose to go all out with though was melee specialists... with the number of "trainable" perks from various people... one on one you can be the cheapest bastard ever... about every attack nocks your apponent down, and even the most powerful apponent just lies there as you beat them senslesly.
Listen well. Everything I tell you is a lie. Every question I ask you is a trick. You will find no truth in me. Though you believe nothing else, you may rest your faith in this.
hehe 9mm exstended mags + scope = ftw!
my main character