Mass Effect 3

[Heretic]

The next one could just be a prequel. Maybe giving more insight into the protheans and the other races/civilizations that were destroyed by the reapers. I think they'd have a hard time making another ME game to take place after ME3 since they'd have to make new baddies and the reapers would be hard to top. Of course, that doesn't mean they won't try anyways.

Also, I played all 3, loved all 3, and I still enjoyed the re-made ending to ME3. I refused to play ME3 before they redid the ending though. I think it's also worthwhile to go watch at least one of the ME3 indoctrination theory videos and their take on the "choices" you make at the end. AngryJoe has an indoctrination theory video even. I wouldn't recommend watching the entire 1.5 HOUR long indoctrination theory documentary though, that one was a bit too long.